个人基本情况：

刘雅妮，博士，讲师，中共党员。2025年6月毕业于南京大学生命科学学院生物学专业，获博士学位；2026年1月至今。就职于合肥大学生命健康与环境工程学院。

目前长期从事化学生物学、小分子荧光探针及神经系统疾病、肿瘤诊断等交叉领域研究。以第一作者或共同第一作者身份在AdvancedScience、AnalyticalChemistry、CellChemical Biology等高水平学术期刊发表学术论文多篇。主持国家自然科学基金青年项目（C类）、合肥大学人才科研基金项目，作为主要成员参与国家自然科学基金面上项目多项。

科研项目：

1、国家自然科学基金青年科学基金项目（C类），No.2260070134，2027-2029，主持；

2、合肥大学人才科研基金项目，No.22040426041，2026-2028，主持。

研究方向：

1. 癫痫疾病的化学调控研究

2. 肿瘤关键靶标蛋白研究

3. 脑部脂滴的动态分布研究

讲授课程：

《基因工程》、《药物化学》、《有机化学》、《绿色生物制造》等

部分代表性论文：

1.Liu,Yani;Yuan, Jiwen; Zhang, Tuanjie; Cai, Xinyi; Xu, Meng; Wang, Xueao; Wang,Rui; Zhang, Bing; Zhu, Hai-Liang; Qian, Yong.H₂O₂-activated serotonin precursor probe for mapping neuronalredox homeostasis reveals 5-HT interactions with neighboring proteinsunder oxidative stress. AdvancedScience.2025, 12(39), e02360.

2.Liu,Yani;Wang, Xueao; Li, Zheng; Chen, Liping; Cai, Xinyi; Sun, Zhigang;Cheng, Wei; Luo, Xiangjie; Zhu, Hai-Liang; Qian, Yong. CascadingDetection of Hydrogen Sulfide and N-Acetyltransferase 2 inHepatocellular Carcinoma Cells Using a Two-Photon Fluorescent Probe.AnalyticalChemistry.2024, 96, 18, 7005–7013.

3.Liu,Yani;Luo, Xiangjie; Cheng, Wei; Zhou, Ling; Zhou, Yang; Zhu, Hai-Liang;James, Tony D; Qian, Yong. Mapping of β3-Adrenergic Receptor inLiving Cells with a Ligand-Guided Fluorescent Probe. AnalyticalChemistry.2024,96(45), 18020-18028.

4.Liu,Yani;Wang, Xueting; Zhang, Chenrun; Shao, Yiwen; Cai, Xinyi; Liu, Huan;Zhu, Hai-Liang; Liu, Xinhua; Qian, Yong; Wang Xueao. An Ultra-LargeStokes Shift Probe for Real-Time Decoding of LysosomalAcidification-Driven Aβ Endocytic Dysregulation in Alzheimer’sDisease.Biosensorsand Bioelectronics.

5.Shao,Chenwen^‡;Liu,Yani^‡;Chen, Zhangpeng; Qin, Yajuan; Wang, Xueao; Wang, Xin; Yan, Chao; Zhu,Hai-Liang; Zhao, Jing; Qian, Yong. 3D two-photon brain imagingreveals dihydroartemisinin exerts antiepileptic effects by modulatingiron homeostasis. CellChemical Biology.2022,29(1), 43-56.e12.

6Wang, Xueao^‡;Liu,Yani^‡;Kim, Subin; Zhang, Chenrun; Li, Zheng; Xu, Chen; Zhu, Hai-Liang;Qian, Y. A two-photon fluorescent probe sensitive to NADPH revealsmetabolic aberrations in brain cells arising from mitochondrialdysfunction in Alzheimer’s disease. ChemicalEngineering Journal.2024,495,153652.

7Wang, Xueao^‡;Liu,Yani^‡;Ye, Xiaolian; Cheng, Wei; Chen, Guiquan; Zhu, Hai-Liang; Zhao, Jing;Qian, Yong. 3D dynamic tracking Aβ plaques in live brains usingvi-nyl-bridged dyes with two-photon excitation/NIR emission and largeStokes shifts. Biosensorsand Bioelectronics.2023, 238: 115563.

8Gu, Jin^‡;Liu,Yani^‡;Shen, Jiawen; Cao, Yuyao; Zhang, Ling; Lu, Yadong; Wang, Baozhong;Zhu, Hai-Liang. A three-channel fluorescent probe for selectivedetection of ONOO− and its application to cell imaging. Talanta.2022,244,123401.

9Shao,Chenwen; Yuan, Jiwen; Liu,Yani;Qin, Yajuan; Wang, Xueao; Gu, Jin; Chen, Guiquan; Zhang, Bing; Liu,Hongke; Zhao, Jing; Zhu, Hai-Liang; Qian, Yong. Epileptic brainfluorescent imaging reveals apigenin can relieve themyeloperoxidase-mediated oxidative stress and inhibit ferroptosis,PNAS.2020, 117 (19), 10155-10164.

联系方式：

liuyn@hfuu.edu.cn